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This is very early - just starting human trials. However it is also a shot at a home run therapy not only for brain tumors but most solid tumors. It is the holy grail of cancer treatments - oral, doesn't hurt normal cells, may work on all cancers by targeting a pathway that is central to all cancers. Will be keeping an eye on this. The trial is open in California now and will open in Arizona soon. https://classic.clinicaltrials.gov/ct2/show/NCT05227326
We have run out of funding and the copay program will remain closed to new and renewal application until we get enough donations to the program to reopen. Of course, we will continue to pay claims for those that have an active grant!
Follow the link in the article to see a short video explaining this new technology that maps out the important areas of the brain so the surgeon knows how much he can take out without doing too much harm. The article also talks about a new advanced radiosurgery system that they will be aquiring soon!
I love this company's plan: they look at failed trials that had some patients do well, and figure out why they failed and which patients benefit. Then they run the trial only on those patients predicted to have a good outcome. One of their first projects is to take Toca511 and TocaFC (now called DB107) and start a trial only for people with the correct biomarker. They did not yet annoucne the biomarker - when they do we can spread word of it and notify people in our database who have that marker. The original early trials of Toca511 looked bery good. I know of a few patients in the trial that did pretty well. However, their large phase 3 randomized trial failed. At that time they did not know which biomarkers predicted success but now they do. It did not help the average patient, but it did help a long tail of people who did have this biomarker!
This is from our friends at Pinpoint Patient Recruiting. We mentioned this recently but they need a few more participants!
They do surveys to learn about the experiences of people dealing with a Glioblastoma. They have a few surveys now. You can do as many as you have time for. They pay you $30 to $105 (depending on the length of the survey) to take the survey, and will also make a donation to the Musella Foundation for every survey you fill out! So please do them!
SurVaxM is an experimental vaccine for the treatment of brain tumors. Early results from a small trial were recently reported Of 63 patients with newly diagnosed Glioblastoma, the median overall survival was 25.9 months from the first dose of the vaccine, which was probably 3-4 months from diagnosis. Our guest speaker is Michael J. Ciesielski, PhD, CEO of Mimivax. This should be of interest to all people dealing with brain tumors.
This is early results on a small number of patients but the results are very good. They started with newly diagnosed patients with unmethylated MGMT who did not have a complete resection. They had only a biopsy or a debulking. This is the worst subset of Glioblastoma. They report of 6 patients, 5 out of the 6 are alive at the 15 month point, and 1 had a complete response, 2 had a 99% response, and 2 had a partial response that was durable! It is very rare to see complete response or 99% response in MGMT unmethylated patients. The trial is ongoing and worth considering for Glioblastoma patients with MGMT unmethylated.
Nice article about one of my favorite neuro-oncologists! He makes great points about disparities not only among minorities but among the elderly and the need to get community doctors involved since 70% of cancer patients are treated in the community setting!
Another successful early trial of a new treatment! They report very early data on five recurrent Glioma patients who have failed all standard treatments. They had one complete response, and two had stable disease. Unfortunately, it appears that this trial is only available in China. Hopefully once it is successful it will be brought to the USA!
The tumor type is Papillary craniopharyngiomas. Although this is a small study of 16 patients, the amazing thing is that no patient’s tumor progressed while on vemurafenib/cobimetinib, and none have died.
The treatment is a combination of a BRAF/MEK inhibitor (vemurafenib/cobimetinib).
If you have any tumor (not just brain - but pancreatic, ovarian, colon, melanoma, etc) with alterations in BRAF / MEK, it may be worth it to show your doctor this article. Both drugs are FDA approved so this should be easy to get - although expensive at about $13,000 per month. If you can not get these drugs, xCures (our partner) is running an expanded access program for another MAPK inhibitor for tumors with any of these alterations: KRAS, NRAS, HRAS, BRAF, MEK, and ERK mutations.
This shows the importance of getting genomic testing for your tumor. It has actionable results in a minority of cases but when it find the right markers, it opens the door to using targeted drugs that may help a lot.
SurVaxM is an experimental vaccine for the treatment of brain tumors. Early results from a small trial were recently reported Of 63 patients with newly diagnosed Glioblastoma, the median overall survival was 25.9 months from the first dose of the vaccine, which was probably 3-4 months from diagnosis. Our guest speaker is Michael J. Ciesielski, PhD, CEO of Mimivax.
This shows the need for better treatments. The biggest criticism I get about the Promising Pathway Act that I have been supporting is "Patients do not want treatments that are not fully tested." Read the statistics from this article and consider if you were in such a situation, would you be open to trying a treatment that showed good results in phase 2 trials, or would you rather wait 5-10 year for them to complete the phase 3 trials?
This article talks about using 5ALA to find tumor cells outside of the area that shows up as tumor on MRI. They conclude that it would be useful to analyze these cells for targeted therapies but missed the obvious use: sonodynamic therapy. If 5ALA can find the tumor cells outside of the main tumor which doesn't show up on MRI, then using focused ultrasound to kill the cells that take up 5ALA may be effective in preventing recurrence.
ALL expanded access treatments should be tracked in a virtual trial. We did it with the Onc-201 expanded access program and it worked out great.
PLEASE help support this bill. You can make a huge difference. I want everyone reading this to email their representatives, and ask 10 of their friends or family to also write. Spread word on social media! Follow the link below for a simple way to send the emails!
This is only a small phase 1 study but they report outstanding results - 26.1 month median survival for DIPG, where the historical average is about 10 months.
Impressive results for recurrent gbm patients with inoperable tumors.
In this podcast hosted by Dr. Sanjay Juneja (the OncDoc on social media), Dr Ely Benaim from SonAlAsense talks about Sonodynamic therapy. This is one of the most promising treatments for not only brain tumors but possibly for any type of cancer. There are clinical trials going on now for recurrent GBM and DIPG. For details go to https://www.sonalasense.com/
There is a different trial going on now with a similiar technology that can also treat patients with multifocal GBM.
Thanks to generous donations, we are able to reopen our copay assistance program! We have a lookback period of 3 months from when the completed application arrives so if you are approved, and have paid for a covered treatment in the last 3 months we can reimburse you! This program can help pay for the following treatments: Optune, Temodar, Avastin and Gleostine, as well as the generics / bioequivalents of these! If you think you may need help, apply ASAP as the program might not be open too long. Remember, seeking help is never something to feel guilty about. We are here to alleviate some of the burdens in your life and provide support during challenging times. Don't hesitate to reach out and let us assist you.
